Upstream Bio, Inc., a clinical-stage biotechnology company, develops treatments for inflammatory diseases focusing on severe respiratory disorders. It offers verekitug, which is in Phase 2 trials for the treatment of severe asthma and chronic rhinosinusitis with nasal polyps and chronic obstructive pulmonary disease and in Phase I clinical trial for treating chronic obstructive pulmonary disease. The company was incorporated in 2021 and is headquartered in Waltham, Massachusetts. Show more

890 Winter Street, Waltham, MA, 02451, United States

Biotechnology

Healthcare

Market Cap

517M

52 Wk Range

$5.14 - $33.68

Previous Close

$9.31

Open

$9.06

Volume

537,603

Day Range

$8.96 - $9.64

Enterprise Value

166.4M

Cash

341.5M

Avg Qtr Burn

-30.63M

Insider Ownership

14.86%

Institutional Own.

94.73%

Qtr Updated

12/31/25

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Drug & Indication	Stage & Event	Catalyst Date
Verekitug Details Severe asthma	Phase 3 Initiation	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
Verekitug Details Chronic Rhinosinusitis with Nasal Polyps (CRSwNP)	Phase 3 Initiation	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
Verekitug Details Chronic Obstructive Pulmonary Disease (COPD)	Phase 2 Data readout	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.