Palisade Bio, Inc., a clinical-stage biopharmaceutical company, engages in developing oral phosphodiesterase-4 inhibitor prodrugs designed for targeted delivery to the terminal ileum and colon in the United States. Its lead clinical product candidate includes PALI-2108, which is in phase 1b clinical trial to treat patients with inflammatory bowel disease, including ulcerative colitis and Fibrostenotic Crohn's disease. The company has a research collaboration and license agreement with Giiant Pharma, Inc. for the development, manufacture, and commercialization of its compounds; license agreement with the Regents of the University of California for sole purpose of maintaining the Newsoara Co-Development; and a co-development and distribution agreement with Newsoara Biopharma Co., Ltd. The company was founded in 2001 and is headquartered in Denver, Colorado. Show more

4600 South Syracuse Street, Denver, CO, 80237, United States

Biotechnology

Healthcare

Market Cap

316.8M

52 Wk Range

$0.53 - $2.64

Previous Close

$1.88

Open

$1.85

Volume

2,540,218

Day Range

$1.81 - $1.92

Enterprise Value

180.6M

Cash

133.4M

Avg Qtr Burn

-3.144M

Insider Ownership

0.03%

Institutional Own.

82.46%

Qtr Updated

12/31/25

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Drug & Indication	Stage & Event	Catalyst Date
PALI-2108 Details Ulcerative colitis	Phase 2 Initiation	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
PALI-2108 (PDE4 Inhibitor Prodrug) Details Moderate To Severe Crohn’s Disease	Phase 2 Initiation	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
PALI-2108 Details Fibrostenotic Crohn’s Disease	Phase 1b Update	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.