NextCure, Inc., a clinical-stage biopharmaceutical company, engages in advancing medicines to treat cancer. The company's product candidate is the LNCB74, a B7-H4 targeted ADC to kill tumors. It also develops NC410, a fusion protein of LAIR-2, that is designed to block immune suppression mediated by LAIR-1; NC525, a novel LAIR-1 antibody that targets acute myeloid leukemia, blast cells, and leukemic stem cells; NC181 a humanized antibody targeting ApoE4 for the treatment of Alzheimer's disease; and NC605 an antibody that targets Siglec-15, as well as chronic bone diseases, such as osteoarthritis and non-union fractures. The company also develop SIM0505, a novel antibody-drug conjugate (ADC) targeting CDH6 (cadherin-6 or K-cadherin) for the treatment of solid tumors. The company was incorporated in 2015 and is headquartered in Beltsville, Maryland. Show more

9000 Virginia Manor Road, Beltsville, MD, 20705, United States

https://www.nextcure.com

Biotechnology

Healthcare

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Market Cap

38.17M

52 Wk Range

$2.69 - $15.74

Previous Close

$10.53

Open

$10.31

Volume

10,785

Day Range

$10.31 - $10.72

Enterprise Value

719.3K

Cash

41.82M

Avg Qtr Burn

-7.638M

Insider Ownership

15.18%

Institutional Own.

49.04%

Qtr Updated

12/31/25

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Drug & Indication	Stage & Event	Catalyst Date
NC410 (LAIR-2 fusion)+ pembrolizumab Details Cancer, Ovarian cancer, Colorectal cancer	Phase 1b Update	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
LNCB74 (B7-H4 ADC) Details Solid tumor/s, Cancer, Ovarian cancer, Breast cancer, Endometrial cancer	Phase 1 Data readout	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
SIM0505 (CDH6 ADC) Details Advanced solid tumors	Phase 1 Data readout	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
NC525 (LAIR-1 mAb) Details Solid tumor/s, Cancer, Acute myeloid leukemia	Phase 1a Update	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
NC318 (S15) + pembrolizumab Details Solid tumor/s, Cancer	Failed Discontinued	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
NC318 (S15) Details Solid tumor/s, Cancer, Triple-negative breast cancer , Head and neck squamous cell carcinoma	Failed Discontinued	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
NC762 (B7-H4 mAb) Details Cancer, Solid tumor/s, Lung cancer, Ovarian cancer, Breast cancer	Failed Discontinued	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.