Alumis Inc., a clinical stage biopharmaceutical company, focuses on the development and commercialization of medicines for autoimmune disorders. The company offers envudeucitinib, a tyrosine kinase 2 (TYK2) inhibitor for the treatment of plaque psoriasis and systemic lupus erythematosus; and A-005, a central nervous system-penetrant allosteric TYK2 inhibitor that is in Phase 1 for the treatment of neuroinflammatory and neurodegenerative diseases. It also develops lonigutamab, a monoclonal antibody targeting IGF-1R for the treatment of thyroid eye diseases; and interferon regulatory factor 5 (IRF5) to address immune dysfunction. The company was formerly known as Esker Therapeutics, Inc. and changed its name to Alumis Inc. in January 2022. Alumis Inc. was incorporated in 2021 and is headquartered in South San Francisco, California. Show more

280 East Grand Avenue, South San Francisco, CA, 94080, United States

Biotechnology

Healthcare

Market Cap

2.891B

52 Wk Range

$2.76 - $30.60

Previous Close

$22.73

Open

$21.96

Volume

1,412,226

Day Range

$21.62 - $23.89

Enterprise Value

2.62B

Cash

308.5M

Avg Qtr Burn

-71.91M

Insider Ownership

0.62%

Institutional Own.

71.78%

Qtr Updated

12/31/25

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Drug & Indication	Stage & Event	Catalyst Date
ESK-001 Details Moderate-to-severe plaque psoriasis	NDA Submission	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
ESK-001 Details Systemic lupus erythematosus	Phase 2b Data readout	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
A-005 Details Multiple sclerosis	Phase 2 Initiation	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.
Lonigutamab (IGF-1R Antibody) Details Thyroid Eye Disease	Phase 1/2 Update	Some catalyst date You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details. You must sign up to see the catalyst details.Sign up now.